Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.

Handzlik, Michal K; Gengatharan, Jivani M; Frizzi, Katie E; McGregor, Grace H; Martino, Cameron; Rahman, Gibraan; Gonzalez, Antonio; Moreno, Ana M; Green, Courtney R; Guernsey, Lucie S; Lin, Terry; Tseng, Patrick; Ideguchi, Yoichiro; Fallon, Regis J; Chaix, Amandine; Panda, Satchidananda; Mali, Prashant; Wallace, Martina; Knight, Rob; Gantner, Marin L; Calcutt, Nigel A; Metallo, Christian M.

Nature ; 614(7946): 118-124, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36697822

2.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

Jung, Su Myung; Hung, Chien-Min; Hildebrand, Samuel R; Sanchez-Gurmaches, Joan; Martinez-Pastor, Barbara; Gengatharan, Jivani M; Wallace, Martina; Mukhopadhyay, Dimpi; Martinez Calejman, Camila; Luciano, Amelia K; Hsiao, Wen-Yu; Tang, Yuefeng; Li, Huawei; Daniels, Danette L; Mostoslavsky, Raul; Metallo, Christian M; Guertin, David A.

Mol Cell ; 75(4): 807-822.e8, 2019 08 22.

Artigo em Inglês | MEDLINE | ID: mdl-31442424

3.

Serine restriction alters sphingolipid diversity to constrain tumour growth.

Muthusamy, Thangaselvam; Cordes, Thekla; Handzlik, Michal K; You, Le; Lim, Esther W; Gengatharan, Jivani; Pinto, Antonio F M; Badur, Mehmet G; Kolar, Matthew J; Wallace, Martina; Saghatelian, Alan; Metallo, Christian M.

Nature ; 586(7831): 790-795, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32788725

4.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.

Acevedo, Aracely; Jones, Anthony E; Danna, Bezawit T; Turner, Rory; Montales, Katrina P; Benincá, Cristiane; Reue, Karen; Shirihai, Orian S; Stiles, Linsey; Wallace, Martina; Wang, Yibin; Bertholet, Ambre M; Divakaruni, Ajit S.

J Biol Chem ; 300(3): 105702, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38301896

5.

MYC protein helps cancer to take its vitamins.

Wallace, Martina.

Nature ; 624(7991): 258-260, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38086940

6.

CRY2 and FBXL3 Cooperatively Degrade c-MYC.

Huber, Anne-Laure; Papp, Stephanie J; Chan, Alanna B; Henriksson, Emma; Jordan, Sabine D; Kriebs, Anna; Nguyen, Madelena; Wallace, Martina; Li, Zhizhong; Metallo, Christian M; Lamia, Katja A.

Mol Cell ; 64(4): 774-789, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27840026

7.

Tracing insights into de novo lipogenesis in liver and adipose tissues.

Wallace, Martina; Metallo, Christian M.

Semin Cell Dev Biol ; 108: 65-71, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32201132

8.

Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.

Gantner, Marin L; Eade, Kevin; Wallace, Martina; Handzlik, Michal K; Fallon, Regis; Trombley, Jennifer; Bonelli, Roberto; Giles, Sarah; Harkins-Perry, Sarah; Heeren, Tjebo F C; Sauer, Lydia; Ideguchi, Yoichiro; Baldini, Michelle; Scheppke, Lea; Dorrell, Michael I; Kitano, Maki; Hart, Barbara J; Cai, Carolyn; Nagasaki, Takayuki; Badur, Mehmet G; Okada, Mali; Woods, Sasha M; Egan, Catherine; Gillies, Mark; Guymer, Robyn; Eichler, Florian; Bahlo, Melanie; Fruttiger, Marcus; Allikmets, Rando; Bernstein, Paul S; Metallo, Christian M; Friedlander, Martin.

N Engl J Med ; 381(15): 1422-1433, 2019 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-31509666

9.

Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children.

Sawh, Mary Catherine; Wallace, Martina; Shapiro, Emma; Goyal, Nidhi P; Newton, Kimberly P; Yu, Elizabeth L; Bross, Craig; Durelle, Janis; Knott, Cynthia; Gangoiti, Jon A; Barshop, Bruce A; Gengatharan, Jivani M; Meurs, Noah; Schlein, Alexandra; Middleton, Michael S; Sirlin, Claude B; Metallo, Christian M; Schwimmer, Jeffrey B.

J Pediatr Gastroenterol Nutr ; 72(4): e90-e96, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33399331

10.

RalA controls glucose homeostasis by regulating glucose uptake in brown fat.

Skorobogatko, Yuliya; Dragan, Morgan; Cordon, Claudia; Reilly, Shannon M; Hung, Chao-Wei; Xia, Wenmin; Zhao, Peng; Wallace, Martina; Lackey, Denise E; Chen, Xiao-Wei; Osborn, Olivia; Bogner-Strauss, Juliane G; Theodorescu, Dan; Metallo, Christian M; Olefsky, Jerrold M; Saltiel, Alan R.

Proc Natl Acad Sci U S A ; 115(30): 7819-7824, 2018 07 24.

Artigo em Inglês | MEDLINE | ID: mdl-29915037

11.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.

Wallace, Martina; Green, Courtney R; Roberts, Lindsay S; Lee, Yujung Michelle; McCarville, Justin L; Sanchez-Gurmaches, Joan; Meurs, Noah; Gengatharan, Jivani M; Hover, Justin D; Phillips, Susan A; Ciaraldi, Theodore P; Guertin, David A; Cabrales, Pedro; Ayres, Janelle S; Nomura, Daniel K; Loomba, Rohit; Metallo, Christian M.

Nat Chem Biol ; 14(11): 1021-1031, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30327559

12.

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.

Green, Courtney R; Wallace, Martina; Divakaruni, Ajit S; Phillips, Susan A; Murphy, Anne N; Ciaraldi, Theodore P; Metallo, Christian M.

Nat Chem Biol ; 12(1): 15-21, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26571352

13.

Gut microbiota composition correlates with diet and health in the elderly.

Claesson, Marcus J; Jeffery, Ian B; Conde, Susana; Power, Susan E; O'Connor, Eibhlís M; Cusack, Siobhán; Harris, Hugh M B; Coakley, Mairead; Lakshminarayanan, Bhuvaneswari; O'Sullivan, Orla; Fitzgerald, Gerald F; Deane, Jennifer; O'Connor, Michael; Harnedy, Norma; O'Connor, Kieran; O'Mahony, Denis; van Sinderen, Douwe; Wallace, Martina; Brennan, Lorraine; Stanton, Catherine; Marchesi, Julian R; Fitzgerald, Anthony P; Shanahan, Fergus; Hill, Colin; Ross, R Paul; O'Toole, Paul W.

Nature ; 488(7410): 178-84, 2012 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-22797518

14.

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.

Cordes, Thekla; Wallace, Martina; Michelucci, Alessandro; Divakaruni, Ajit S; Sapcariu, Sean C; Sousa, Carole; Koseki, Haruhiko; Cabrales, Pedro; Murphy, Anne N; Hiller, Karsten; Metallo, Christian M.

J Biol Chem ; 291(27): 14274-14284, 2016 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-27189937

15.

Metabolomic analysis of pancreatic beta cells following exposure to high glucose.

Wallace, Martina; Whelan, Helena; Brennan, Lorraine.

Biochim Biophys Acta ; 1830(3): 2583-90, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23153904

16.

Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain.

O'Sullivan, Aifric; Brady, Emer; Lafferty, Lucy; O'Shea, Fiona; O'Regan, Zoe; Meurs, Noah; Baldini, Michelle; Gengatharan, Jivani; Metallo, Christian M; Wallace, Martina.

Prostaglandins Leukot Essent Fatty Acids ; 201: 102607, 2024 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-38277883

17.

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide.

Turner, Rory; Mukherjee, Rajib; Wallace, Martina; Sanchez-Gurmaches, Joan.

J Vis Exp ; (195)2023 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-37246886

18.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.

Acevedo, Aracely; Jones, Anthony E; Danna, Bezawit T; Turner, Rory; Montales, Katrina P; Benincá, Cristiane; Reue, Karen; Shirihai, Orian S; Stiles, Linsey; Wallace, Martina; Wang, Yibin; Bertholet, Ambre M; Divakaruni, Ajit S.

bioRxiv ; 2023 Aug 16.

Artigo em Inglês | MEDLINE | ID: mdl-37645724

19.

Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease.

Green, Courtney R; Bonelli, Roberto; Ansell, Brendan R E; Tzaridis, Simone; Handzlik, Michal K; McGregor, Grace H; Hart, Barbara; Trombley, Jennifer; Reilly, Mary M; Bernstein, Paul S; Egan, Catherine; Fruttiger, Marcus; Wallace, Martina; Bahlo, Melanie; Friedlander, Martin; Metallo, Christian M; Gantner, Marin L.

Mol Metab ; 72: 101716, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-36997154

20.

iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.

Eade, Kevin T; Ansell, Brendan Robert E; Giles, Sarah; Fallon, Regis; Harkins-Perry, Sarah; Nagasaki, Takayuki; Tzaridis, Simone; Wallace, Martina; Mills, Elizabeth A; Farashi, Samaneh; Johnson, Alec; Sauer, Lydia; Hart, Barbara; Diaz-Rubio, M Elena; Bahlo, Melanie; Metallo, Christian; Allikmets, Rando; Gantner, Marin L; Bernstein, Paul S; Friedlander, Martin.

J Clin Invest ; 133(9)2023 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-37115691

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Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

Serine restriction alters sphingolipid diversity to constrain tumour growth.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.

MYC protein helps cancer to take its vitamins.

CRY2 and FBXL3 Cooperatively Degrade c-MYC.

Tracing insights into de novo lipogenesis in liver and adipose tissues.

Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.

Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children.

RalA controls glucose homeostasis by regulating glucose uptake in brown fat.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.

Gut microbiota composition correlates with diet and health in the elderly.

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.

Metabolomic analysis of pancreatic beta cells following exposure to high glucose.

Long chain monomethyl branched-chain fatty acid levels in human milk vary with gestational weight gain.

Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.

Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease.

iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.